abstract：OBJECTIVES:Estrogen is often prescribed for symptoms and sequelae of ovarian estrogen loss after menopause. METHODS:To assess efficacy and acceptability of a new, highly soluble estrogen-calcium preparation, we formulated a water-soluble powdered combination of estrogen (0.625 mg estrone piperazine sulfate) and calciu...

journal_title：Maturitas

authors： Downey D,Spencer SJ,Deghenghi R,Jaffe RB

更新日期：2001-04-20 00:00:00

abstract：:S21400 (AERODIOL) is a new intranasal formulation of 17beta-estradiol. It provides a pulsed estrogen therapy that ensures sufficient estrogenisation of tissues to treat estrogen deficiency symptoms, particularly those of the menopause. This multicentric study was designed to determine dose-range, efficacy and acceptab...

journal_title：Maturitas

authors： Pelissier C,de Kervasdoue A,Chuong VT,Maugis EL,de Mouillac F,Breil MH,Moniot G,Zeitoun-Lepvrier G,Robin M,Rime B

更新日期：2001-01-31 00:00:00

abstract：OBJECTIVES:The menopause rating scale (MRS) has been developed as a modern tool for the assessment of menopausal complaints. It combines in practice excellent applicability and a good reliability, and there are normal values for the population available. For further practical evaluation, the MRS was applied in order to...

journal_title：Maturitas

authors： Schneider HP,Rosemeier HP,Schnitker J,Gerbsch S,Turck R

更新日期：2000-12-29 00:00:00

abstract：OBJECTIVES:It is still controversial whether hormone replacement therapy (HRT) can affect the onset of uterine myomas or their growth in postmenopause. It is likely that some therapeutic schedules can influence the myometrial growth differently, due to a more potent stimulation of the uterine receptors. The aim of the ...

journal_title：Maturitas

authors： Polatti F,Viazzo F,Colleoni R,Nappi RE

更新日期：2000-11-30 00:00:00

abstract：OBJECTIVES:To study the fracture reducing potential of hormonal replacement therapy (HRT) in recent postmenopausal women in a primary preventive scenario. METHODS:Prospective controlled comprehensive cohort trial: 2016 healthy women aged 45-58 years, from three to 24 months past last menstrual bleeding were recruited ...

journal_title：Maturitas

authors： Mosekilde L,Beck-Nielsen H,Sørensen OH,Nielsen SP,Charles P,Vestergaard P,Hermann AP,Gram J,Hansen TB,Abrahamsen B,Ebbesen EN,Stilgren L,Jensen LB,Brot C,Hansen B,Tofteng CL,Eiken P,Kolthoff N

更新日期：2000-10-31 00:00:00

abstract：OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland...

journal_title：Maturitas

authors： Leimola-Virtanen R,Salo T,Toikkanen S,Pulkkinen J,Syrjänen S

更新日期：2000-08-31 00:00:00

abstract：OBJECTIVES:mitral annular calcification (MAC) occurs mainly in middle-aged and elderly patients and can lead to serious clinical consequences. Male predominance in the prevalence of coronary disease is well-established. Paradoxically, the prevalence of MAC, which is theoretically based on the same etiological mechanism...

journal_title：Maturitas

authors： Tenenbaum A,Fisman EZ,Pines A,Shemesh J,Shapira I,Adler Y,Frenkel Y,Boyko V,Motro M

更新日期：2000-07-31 00:00:00

abstract：OBJECTIVES:To evaluate the effect of estrogen replacement therapy (ERT) on postmenopausal bone loss by multi-site ultrasound measurement. METHODS:A cross-sectional comparison of postmenopausal women, ERT users and non-users. The two study groups were enrolled for the reference database collection for the Sunlight Omni...

journal_title：Maturitas

authors： Weiss M,Ben Shlomo A,Hagag P,Rapoport M,Ish-Shalom S

更新日期：2000-06-30 00:00:00

abstract：:To analyse the relationship between nocturnal micturition and health in 40- to 64-year-old women. A questionnaire study was carried out in 3669 randomly selected women (out of 6000 invited) in the County of Jämtland, Sweden. Questions were asked about the general health status of health, health development during the ...

journal_title：Maturitas

authors： Asplund R,Aberg HE

更新日期：2000-05-29 00:00:00

abstract：OBJECTIVES:To study whether dose adjustments in transdermal estradiol gel treatment would result in proportional changes in estradiol bioavailability and concentrations. METHODS:In an open study, 23 healthy postmenopausal women were treated consecutively with 0.5, 1.0 and 1.5 mg estradiol daily as a transdermal gel. E...

journal_title：Maturitas

authors： Järvinen A,Granander M,Laine T,Viitanen A

更新日期：2000-04-28 00:00:00

abstract：OBJECTIVES:The current study investigated the neurotrophic and neuroprotective action of the complex formulation of conjugated equine estrogens (CEEs), the most frequently prescribed estrogen replacement therapy in the United States and the estrogen replacement therapy of the Women's Health Initiative. METHODS:Videomi...

journal_title：Maturitas

authors： Brinton RD,Chen S,Montoya M,Hsieh D,Minaya J

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVES:The effects of hormone replacement therapy on cardiovascular risk factors in postmenopausal women with non-insulin dependent diabetes mellitus (type II diabetes) is uncertain. METHODS:The effects of estrogen replacement therapy (ERT, conjugated equine estrogen0.625mg orally daily), combined estrogen and con...

journal_title：Maturitas

authors： Manwaring P,Morfis L,Diamond T,Howes LG

更新日期：2000-03-31 00:00:00

abstract：OBJECTIVE:To investigate the relationship between the timing of withdrawal bleeding on hormone replacement therapy and the state of the endometrium. DESIGN:Double-blind, prospectively randomised dose-ranging study. SETTING:Menopause clinics in the UK and the Netherlands. SUBJECTS:Two hundred and seventy one postmeno...

journal_title：Maturitas

authors： Burch D,Bieshuevel E,Smith S,Fox H

更新日期：2000-02-15 00:00:00

abstract：OBJECTIVES:Bone mineral density (BMD) and development of osteoporosis are partly determined by genetic factors. The associations between one of suggested candidate, apolipoprotein E (apo E) genotype to bone mineral density (BMD) and bone biochemical markers was studied in 464 subjects recruited from a population-based ...

journal_title：Maturitas

authors： Heikkinen AM,Kröger H,Niskanen L,Komulainen MH,Ryynänen M,Parviainen MT,Tuppurainen MT,Honkanen R,Saarikoski S

更新日期：2000-01-15 00:00:00

abstract：:Hormone replacement therapy may increase the quality of life of postmenopausal women. Any regimen need to offer long-term endometrial safety. It is a standard to consider the co-administration of a sequential progestogen when estrogen replacement should be initiated in non-hysterectomized women. It is almost impossibl...

journal_title：Maturitas

authors： Dören M

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:this paper aims to report the prevalence of symptoms in the Hong Kong Chinese perimenopausal women; to construct reported symptoms into symptom groupings; and to clarify whether the symptom groups are associated with menopausal status. METHODS:a random telephone survey of perimenopausal women aged 44-55 yea...

journal_title：Maturitas

authors： Ho SC,Chan SG,Yip YB,Cheng A,Yi Q,Chan C

更新日期：1999-12-15 00:00:00

abstract：AIMS:Women in the West can now expect to live one third of their life in a postmenopausal state, and consequently in a state of estrogen deficiency. This can have a number of consequences, and many women suffer vasomotor symptoms during the climacteric. Estrogen deficiency can also result in changes to the skin, hair, ...

journal_title：Maturitas

authors： Palacios S

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:To compare the effects of (i) continuous low dosage C-19 progestin (dl-norgestrel, NG) plus cyclical conjugated estrogen (CEE) versus (ii) continuous low dosage C-21 progestin [medroxyprogesterone acetate (MPA)] plus CEE on postmenopausal vaginal bleeding, mood and somatic, psychosomatic and psychological sym...

journal_title：Maturitas

authors： Wolfe BM,Koval JJ,Nisker JA

更新日期：1999-10-24 00:00:00

abstract：OBJECTIVE:Sales figures for the use of menopausal and postmenopausal hormone therapy in Finland show a rapid increase during the 1980s continued into the first half of the 1990s. Hormone therapy use became very common in Finland compared to many other Western countries. The aim of our study was to investigate the socio...

journal_title：Maturitas

authors： Topo P,Luoto R,Hemminki E,Uutela A

更新日期：1999-08-16 00:00:00

abstract：OBJECTIVE:In 1990 we initiated a 20 year, partly randomised study (Danish Osteoporosis Prevention Study, DOPS) in order to (a) evaluate clinical, biochemical and osteodensitometric variables as predictors of low bone mass and future osteoporotic fractures, and (b) test the hypothesis, that hormone replacement therapy (...

journal_title：Maturitas

authors： Mosekilde L,Hermann AP,Beck-Nielsen H,Charles P,Nielsen SP,Sørensen OH

更新日期：1999-03-15 00:00:00

abstract：OBJECTIVES:To investigate the effect of vitamin K2 treatment for a year on spinal bone mineral density (BMD) in postmenopausal women, comparing with vitamin D3 hormone replacement therapy and to determine the factors which affect the efficacy of vitamin K2 therapy. SUBJECTS AND METHODS:Seventy-two postmenopausal women...

journal_title：Maturitas

authors： Iwamoto I,Kosha S,Noguchi S,Murakami M,Fujino T,Douchi T,Nagata Y

更新日期：1999-01-04 00:00:00

abstract：:Tibolone appears to be at least as efficacious as other forms of hormonal replacement therapy (HRT) on climacteric symptoms. It does not cause withdrawal bleeding when used in women with at least 1 year of amenorrhea. It is, therefore, not indicated in perimenopause because it may cause irregular bleeding. The androge...

journal_title：Maturitas

authors： Albertazzi P,Di Micco R,Zanardi E

更新日期：1998-11-16 00:00:00

abstract：OBJECTIVES:Cryostorage of ovarian cortical tissue, before devastating chemo- and/or radiotherapy for cancer, permits survival of primordial and early preantral follicles. This work aims for a system allowing the long-term maturation in vitro (IVM) of small immature oocytes up to fertilisable metaphase II oocytes. METH...

journal_title：Maturitas

authors： Smitz J,Cortvrindt R

更新日期：1998-10-12 00:00:00

abstract：:Hormone replacement therapy (HRT) in postmenopausal women is associated with a reduction in the risk of developing coronary artery disease (CAD) of about 50%. Women with an elevated risk for CAD appear to benefit most by HRT. The HRT-associated cardiovascular protection may be related to favourable changes in several ...

journal_title：Maturitas

authors： van der Mooren MJ,Mijatovic V,van Baal WM,Stehouwer CD

更新日期：1998-09-20 00:00:00

abstract：OBJECTIVES:To determine the median age of natural menopause in United Arab Emirates women, the factors affecting that age and the prevalence of climacteric symptoms amongst those women. METHODS:A population-based survey was conducted on a community sample of United Arab Emirates women who had had natural menopause def...

journal_title：Maturitas

authors： Rizk DE,Bener A,Ezimokhai M,Hassan MY,Micallef R

更新日期：1998-06-17 00:00:00

abstract：OBJECTIVES:In one of the earlier hypotheses of the etiology of breast cancer (Korenman's 'oestrogen window' hypothesis (1981)), it was assumed that women with a later age at menopause have a longer period with irregular cycles preceding menopause than women with an early menopause. This assumption was tested in a prosp...

journal_title：Maturitas

authors： den Tonkelaar I,te Velde ER,Looman CW

更新日期：1998-06-03 00:00:00

abstract：BACKGROUND:There is some evidence that hormone replacement therapy may produce significant improvements in fine wrinkling, while aging skin is more frequently found in smokers. However, studies of the combined effect of a protective factor, such as HRT, and a damaging factor, such as smoking, are rare. OBJECTIVES:To d...

journal_title：Maturitas

authors： Castelo-Branco C,Figueras F,Martínez de Osaba MJ,Vanrell JA

更新日期：1998-05-20 00:00:00

abstract：OBJECTIVE:To determine whether percutaneous estradiol (pE2) (1.5 mg/day) is able to counteract the postmenopausal bone loss in postmenopausal hysterectomized women, in a double-blind study versus oral estriol (E3) (2 mg/day). METHODS:The bone mineral density of the lumbar spine (LS) and of the proximal femur (PF) was ...

journal_title：Maturitas

authors： Devogelaer JP,Lecart C,Dupret P,De Nayer P,Nagant De Deuxchaisnes C

更新日期：1998-01-12 00:00:00

abstract：OBJECTIVE:New regimens and routes of administration of hormonal replacement therapy (HRT) in climateric women are becoming available. Since there is no information on the neuroendocrine effects of sequential combined treatment with 17 beta-estradiol and a progestin, the present study evaluated the neuroendocrine, clini...

journal_title：Maturitas

authors： Stomati M,Bersi C,Rubino S,Palumbo M,Comitini G,Genazzani AD,Santuz M,Petraglia F,Genazzani AR

更新日期：1997-12-15 00:00:00

abstract：:We investigated the long-term effects of oral estriol (E3) on bone mineral density (BMD) at the lumbar spine and biochemical indices of bone turnover in early menopausal women. We studied 64 healthy early menopausal women who were treated for 24 months with 2.0 mg E3 plus 2.5 mg medroxyprogesterone acetate daily (E3 g...

journal_title：Maturitas

authors： Itoi H,Minakami H,Sato I

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVES:To compare the metabolic and endocrinological effects of estradiol valerate/cyproterone acetate (EV/CPA) to a regimen of conjugated estrogens/medroxyprogesterone acetate (CE/MPA) in postmenopausal women. METHODS:Lipid profile, endocrinological parameters, coagulation factors, renin and angiotensinogen were ...

journal_title：Maturitas

authors： Bissonnette F,Lussier-Cacan S,Fugère P,Bérubé S

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of estrogen alone or combined with progestin on the amount and synthesis of skin collagen in postmenopausal women. METHODS:Forty-three early postmenopausal women were enrolled into this open, non-randomized parallel-groups study. Fifteen women received a continuous oral dose of 2 m...

journal_title：Maturitas

authors： Haapasaari KM,Raudaskoski T,Kallioinen M,Suvanto-Luukkonen E,Kauppila A,Läärä E,Risteli J,Oikarinen A

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To re-examine the minimal effective dose of conjugated estrogen (CEE)-progestin hormone replacement on postmenopausal bone loss. DESIGN:A 2-year, prospective, open label, randomized study. SETTING:Department of Obstetrics and Gynecology of a university hospital. PARTICIPANTS:Fifty-two postmenopausal or oop...

journal_title：Maturitas

authors： Mizunuma H,Okano H,Soda M,Kagami I,Miyamoto S,Tokizawa T,Honjo S,Ibuki Y

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVES:A cost-effectiveness analysis on osteoporosis treatment has been carried out as the basis for an estimate of the cost per avoided hip fracture (CPAHF) in Italy. METHODS:We have assumed as correct, reported data on the efficacy of calcitonin in preventing hip fractures in European women over 50 (Mediterranea...

journal_title：Maturitas

authors： Visentin P,Ciravegna R,Fabris F

更新日期：1997-04-01 00:00:00

abstract：:The pentraxin serum amyloid P component (SAP) is a 9.5Sz1-glycoprotein and it has recently been found to be deposited in atherosclerotic lesions or neurofibrillary tangles, which are related to the aging process and Alzheimer's disease. The level of SAP was measured by micro single radial-immunodiffusion. Sample sera ...

journal_title：Maturitas

authors： Hashimoto S,Katou M,Dong Y,Murakami K,Terada S,Inoue M

更新日期：1997-03-01 00:00:00

abstract：:This study was a cross-sectional survey of mid-aged Thai women with the following aims: to describe their experience of symptoms and attitudes to menopause and to examine the relationships between symptoms, attitudes to menopause, sociodemographic variables and menopausal status. The sample was 268 women aged between ...

journal_title：Maturitas

authors： Punyahotra S,Dennerstein L,Lehert P

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVES:To examine the potential of a new matrix system developed for estradiol delivery to cause microbial proliferation under the occluded site or to cause acute phototoxicity reactions. METHODS:Twenty healthy post-menopausal women participated in a microbial proliferation study and 11 in a phototoxicity study. B...

journal_title：Maturitas

authors： Mulberry GK,Della-Cioppa G,Monza G,Harper RA,Oelrich DM

更新日期：1996-11-01 00:00:00

abstract：:The occurrence of uterine bleeding usually associated with hormonal replacement therapy is not acceptable for many women. Our objective was to review data on compliance and bleeding patterns in 70 postmenopausal women on oral replacement with estradiol 2 mg, estriol 1 mg, and norethisterone acetate 1 mg daily administ...

journal_title：Maturitas

authors： Dören M,Schneider HP

更新日期：1996-10-01 00:00:00

abstract：:The change in lumbar vertebral bone mineral density (BMD) during a 2-year study period was examined in 167 healthy middle-aged and elderly Japanese women with reference to age, menopausal status and bone turnover markers at baseline. The perimenopausal and postmenopausal groups of the subjects showed a significant los...

journal_title：Maturitas

authors： Iki M,Kajita E,Dohi Y,Nishino H,Kusaka Y,Tsuchida C,Yamamoto K,Ishii Y

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:To develop a condition-specific quality of life questionnaire for the menopause with documented psychometric properties, based on women's experience. METHODS: SUBJECTS:Women 2-7 years post-menopause with a uterus and not currently on hormone replacement therapy. Questionnaire development: A list of 106 meno...

journal_title：Maturitas

authors： Hilditch JR,Lewis J,Peter A,van Maris B,Ross A,Franssen E,Guyatt GH,Norton PG,Dunn E

更新日期：1996-07-01 00:00:00